Frequency and Duration

"There are indicators that are considered to reduce the likelihood of adverse effects of the ENM that are based on the specific exposure scenario under consideration and/or on loss of nano-properties. A complete loss of nano-properties will allow for reliance on a conventional risk assessment and the nano-specific risk assessment procedure would no longer be required.

• Increased rate of dissolution (e.g. in water, food/feed matrix or body fluids)
• Increased rate of degradability (e.g. biological or photocatalytic) to non-nanoform degradation products
• Presence of strongly bound aggregates (e.g. determined by conditions of production), fixed,
  permanent bonding in matrices (e.g. stability of matrix, type of bond, end-of-life behaviour)"¹